{"id":48,"date":"2013-10-27T21:49:42","date_gmt":"2013-10-27T21:49:42","guid":{"rendered":"http:\/\/departamentos.unileon.es\/ciencias-biomedicas-area-farmacologia\/?page_id=48"},"modified":"2026-02-02T19:31:53","modified_gmt":"2026-02-02T19:31:53","slug":"actividad-investigadora","status":"publish","type":"page","link":"https:\/\/departamentos.unileon.es\/ciencias-biomedicas-area-farmacologia\/actividad-investigadora\/","title":{"rendered":"Actividad investigadora"},"content":{"rendered":"<h3><strong><span style=\"color: #0000ff;\">Acceso al grupo de investigaci\u00f3n <\/span><a href=\"https:\/\/portalcientifico.unileon.es\/grupos\/8568\/detalle\"><span style=\"color: #0000ff;\">FARMACOLOG\u00cdA (FARMA01)<\/span><\/a><span style=\"color: #0000ff;\"> en el portal cient\u00edfico de la Universidad de Le\u00f3n.<\/span><\/strong><\/h3>\n<h2>Principales publicaciones<\/h2>\n<ul>\n \t<li>\n<h4><a href=\"https:\/\/www.mdpi.com\/2079-6382\/15\/2\/130\">Determination of gentamicin: Development and validation of a sensitive UPLC-MS\/MS assay according to the European Medicines Agency Guideline<\/a><\/h4>\nDiez R, Vazquez EM, Romero B, de la Puente, Fernandez N, Sahag\u00fan AM, Diez MJ, Lopez C.&nbsp;\nAntibiotics, 15(2):130(2026). doi:10.3390\/antibiotics15020130<\/li>\n \t<li>\n<h4><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40476354\/\">Perioperative drug management in non-critical companion animals: a retrospective study at a Spanish veterinary teaching hospital (2018-2022)<\/a><\/h4>\nRomero B, Susperregui J, Sahag\u00fan AM, Alt\u00f3naga JR, Lopez C, de la Puente R, Rodriguez JM, Vazquez M, D\u00edez R.&nbsp;\nVeterinary Quarterly, 45(1):1-17(2025). doi:10.1080\/01652176.2025.2513965<\/li>\n \t<li>\n<h4><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0025775325003318?via%3Dihub\">Medicaci\u00f3n inadecuada<\/a><\/h4>\nSahag\u00fan AM, D\u00edez R.&nbsp;\nMedicina Cl\u00ednica, 165(3):10703(2025). doi:1<span style=\"color: initial;\">0.1016\/j.medcli.2025.107103<\/span><\/li>\n \t<li>\n<h4><a href=\"https:\/\/www.frontiersin.org\/journals\/veterinary-science\/articles\/10.3389\/fvets.2025.1588840\/full\">Pet cancer cases and patterns of treatment at a Spanish veterinary teaching hospital: A retrospective study from 2015 to 2024<\/a><\/h4>\nRomero B, Susperregui J, D\u00edez R, Vazquez EM, Lopez C, de la Puente R, Diez MJ, Fernandez N, Rodriguez-Altonaga JM, Sahagun AM.&nbsp;\nFrontiers in Veterinary Science, 12:1588840(2025). doi:10.3389\/fvets.2025.1588840<\/li>\n \t<li>\n<h4><a href=\"https:\/\/www.frontiersin.org\/journals\/sustainable-food-systems\/articles\/10.3389\/fsufs.2025.1575428\/full\">Occurrence and risk assessment of organochlorine pesticide residues in tea and herbal products in Spain<\/a><\/h4>\nDiez R, Lopez C, Rodriguez JM, de la Puente R, Romero B, Vazquez EM, Diez MJ, Fernandez N, Sahagun AM.&nbsp;\nFrontiers in Sustainable Food Systems, 9:1575428(2025). doi:10.3389\/fsufs.2025.1575428<\/li>\n \t<li>\n<h4><a href=\"https:\/\/www.mdpi.com\/2306-7381\/11\/11\/519\">Pharmacokinetic of meloxicam in different animal species: A comprehensive review<\/a><\/h4>\nde la Puente, Diez R, Diez MJ, Fernandez N, Sahagun AM, Rodriguez JM, Garc\u00eda JJ, Lopez C.&nbsp;\nVeterinary Sciences, 11:519(2024). doi:10.3390\/vetsci11110519<\/li>\n \t<li>\n<h4><a href=\"https:\/\/www.mdpi.com\/2076-2615\/14\/17\/2540#:~:text=After%20intravenous%20administration%2C%20the%20drug,exhibited%20quick%20and%20high%20absorption.\">Pharmacokinetic pattern of menbutone in calves after single intravenous and intramuscular administration<\/a><\/h4>\nDiez R, Rodriguez JM, Lopez C, de la Puente R, Sierra M, Diez MJ, Fernandez N, Garc\u00eda JJ, Sahagun AM.&nbsp;\nAnimals, 14:2540(2024). doi:10.3390\/ani14172540<\/li>\n \t<li>\n<h4><a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2023.1328698\/full\">Drug prescription pattern in exotic pet and wildlike animal practice: A retrospective study in a Spanish veterinary teaching hospital from 2018 to 2022<\/a><\/h4>\nRomero B, Susperregui J, Sahagun AM, Fernandez N, Lopez C, de la Puente R, Altonaga J, Diez R.\nFrontiers in Veterinary Science, 10(2024). doi:10.3389\/fvets.2023.1328698.<\/li>\n \t<li>\n<h4><a href=\"https:\/\/www.mdpi.com\/2072-6643\/16\/9\/1320\"><em>Tribulus terrestris<\/em> and sport performance: A quantitative and qualitative evaluation of its advertisement and availability via online shopping in six different countries<\/a><\/h4>\nGarcia JF, Seco-Calvo J, Arribalzaga S, Diez R, Lopez C, Fernandez N, Garcia JJ, Diez MJ, de la Puente R, Sierra M, Sahagun AM. &nbsp;\nNutrients, 16:9(2024). doi:10.3390\/nu16091320.<\/li>\n \t<li>\n<h4><a href=\"https:\/\/bmcnurs.biomedcentral.com\/articles\/10.1186\/s12912-023-01172-5\">Face-to-face and online teaching experience on experimental animals and alternative methods with Nursing students: A research study<\/a><\/h4>\nGarcia JF, Fernandez N, Lopez C, Diez R, Rodriguez JM, Sahagun AM. &nbsp;\nBMC Nursing, 22:105(2023). doi:10.1186\/s12912-023-01172-5.<\/li>\n \t<li>\n<h4><a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2022.1060738\/full\">Use of medicinal plants by veterinary practitioners in Spain: A cross-sectional survey<\/a><\/h4>\nRomero B, Susperregui J, Sahagun AM, Diez MJ, Fernandez N, Garcia JJ,&nbsp; Lopez C, Sierra M, Diez R. &nbsp;\nFrontiers in Veterinary Science, 9:1060738(2022). doi:10.3389\/fvets.2022.1060738.<\/li>\n \t<li>\n<h4><a class=\"gsc_a_at\" href=\"https:\/\/www.mdpi.com\/2297-8739\/9\/8\/223\">Development and validation of a sensitive HPLC assay for determination of sparfloxacin according to the European Medicines Agency Guideline<\/a><\/h4>\nLopez C, Diez R, Rodriguez JM, Sierra M, Garcia JJ,&nbsp;Fernandez N,&nbsp; Diez MJ,&nbsp; Sahagun AM\nSeparations, 9:223(2022). doi:10.3390\/separations9080223.<\/li>\n \t<li>\n<h4><a class=\"gsc_a_at\" href=\"https:\/\/www.mdpi.com\/2072-6643\/14\/13\/2764\">Herbs as an active ingredient in sport: Availability and information on the internet<\/a><\/h4>\nGarcia JF, Arrizabalaga S, Diez R, Lopez C, Fernandez N, Garcia JJ,&nbsp; Diez MJ, Seco-Calvo J, Sierra M, Sahagun AM\nNutrients, 14:2764(2022). doi:<span class=\"citation-doi\">10.3390\/nu14132764<\/span>.<\/li>\n \t<li>\n<h4><a class=\"gsc_a_at\" href=\"https:\/\/www.mdpi.com\/2077-0383\/11\/13\/3808\">Potentially inappropriate medication and polypharmacy in Nursing Home residents: A cross-sectional study<\/a><\/h4>\nDiez R, Cadenas R, Susperregui J, Sahagun AM, Fernandez N, Garcia JJ,&nbsp; Sierra M, Lopez C\nJournal of Clinical Medicine, 11:3808(2022). doi:<span class=\"identifier doi\"><span class=\"citation-doi\">10.3390\/jcm11133808<\/span><\/span>.<\/li>\n \t<li>\n<h4><a href=\"https:\/\/www.mdpi.com\/1660-4601\/19\/7\/4313\">Drug-related problems and polypharmacy in Nursing Home residents: A cross-sectional study.<\/a><\/h4>\nDiez R, Cadenas R, Susperregui J, Sahagun AM, Fernandez N, Garcia JJ,&nbsp; Sierra M, Lopez C\nInternational Journal of Environmental Research and Public Health, 19:7(2022). doi:<span class=\"identifier doi\">10.3390\/ijerph19074313<\/span>.<\/li>\n \t<li>\n<h4><a href=\"https:\/\/www.mdpi.com\/2297-8739\/9\/4\/84\">Determination of menbutone: Development and validation of a sensitive HPLC assay according to the European Medicines Agency Guideline<\/a>.<\/h4>\nLopez C, Diez R, Rodriguez JM, Sierra M, Garcia JJ,&nbsp; Fernandez N, Diez MJ, Sahagun AM\nSeparations, 9:84(2022). doi:10.3390\/separations9040084.<\/li>\n \t<li>\n<h4><a href=\"https:\/\/www.mdpi.com\/2076-2615\/12\/4\/463\">Improvement of albendazole bioavailability with menbutone administration in sheep.<\/a><\/h4>\nDiez R, Diez MJ, Garcia JJ, Rodriguez JM, Lopez C, Fernandez N, Sierra M, Sahagun AM\nAnimals, 12:463(2022). doi:<span class=\"identifier doi\">10.3390\/ani12040463<\/span>.<\/li>\n \t<li>\n<h4><a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fvets.2021.798850\/full\">Availability of antibiotics for veterinary use on the internet: A cross-sectional study.<\/a><\/h4>\nGarcia JF, Diez MJ, Sahagun AM, Diez R, Sierra M, Garcia JJ, Lopez C, Fernandez N\nFrontiers in Veterinary Science, 8:798850(2022). doi:<span class=\"identifier doi\">10.3389\/fvets.2021.798850<\/span>.<\/li>\n \t<li>\n<h4><a href=\"https:\/\/www.mdpi.com\/2076-2615\/11\/6\/1514\">Distribution of flumequine in intestinal contents and colon tissue in pigs after Its therapeutic use in the drinking water.<\/a><\/h4>\nRodriguez JM, Diez MJ, Sierra M, Garcia JJ, Fernandez N, Diez R, Sahagun AM\nAnimals, 11:1514(2021). doi:<span class=\"identifier doi\">10.3390\/ani11061514<\/span>.<\/li>\n \t<li>\n<h4><a href=\"https:\/\/www.mdpi.com\/1660-4601\/18\/4\/2037\">Prevalence and associated factors of polypharmacy in nursing home residents: A cross-sectional study.<\/a><\/h4>\nCadenas R, Diez MJ, Fernandez N, Garcia JJ, Sierra M, Lopez C, Susperregui J, Diez R\nInternational Journal of Environmental Research and Public Health, 18:2037(2021). doi:<span class=\"identifier doi\">10.3390\/ijerph18042037<\/span>.<\/li>\n \t<li>\n<h4><a href=\"https:\/\/www.mdpi.com\/2076-2615\/10\/3\/503\">The online sale of antibiotics for veterinary use.<\/a><\/h4>\nGarc\u00eda JF, Diez MJ, Sahag\u00fan AM, Diez R, Sierra M, Garcia JJ, Fernandez N\nAnimals, 10:3(2020). doi:<span class=\"identifier doi\">10.3390\/ani10030503<\/span>.<\/li>\n \t<li>\n<h4><a href=\"http:\/\/www.scholarena.org\/journals\/journal-of-veterinary-and-animal-research\/current-issue.php\">Study of master formulas for animal use in a pharmacy in an experimental animal model.<\/a><\/h4>\nGarc\u00eda V, D\u00edez R, Sahag\u00fan AM, Susperregui J, Fern\u00e1ndez MN, Garc\u00eda JJ, Sierra M, Diez MJ\nJournal of Veterinary and Animal Research, 2:104(2019). doi:10.1186\/s12906-017-1809-x.<\/li>\n \t<li>\n<h4><a href=\"https:\/\/www.mdpi.com\/1420-3049\/24\/11\/2049\">Assessment of the antioxidant\/hypolipidemic relationship of <em>Sideritis hyssopifolia<\/em> in an experimental animal model.<\/a><\/h4>\nCoto E, Fernandez N, Garcia JJ, Diez MJ, Sahagun AM, Sierra M.\nMolecules, 24:2049 (2019). doi:10.1186\/s12906-017-1809-x.<\/li>\n \t<li>\n<h4><a href=\"https:\/\/bmccomplementalternmed.biomedcentral.com\/articles\/10.1186\/s12906-017-1809-x\">Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits.<\/a><\/h4>\nD\u00edez R, Garc\u00eda JJ,Diez MJ, Sahagun AM, Sierra M, Fern\u00e1ndez N.\nBMC Complementary and Alternative Medicine, 17:298 (2017). doi:10.1186\/s12906-017-1809-x.<\/li>\n<\/ul>\n<ul>\n \t<li>\n<h4><a href=\"http:\/\/www.hindawi.com\/journals\/jdr\/aa\/167526\/\">Evaluation of the association metformin: <em>Plantago ovata husk<\/em> in diabetic rabbits.<\/a><\/h4>\nD\u00edez-L\u00e1iz R, Garc\u00eda-Vieitez JJ,Diez-Li\u00e9bana MJ, Sierra-Vega M, Sahag\u00fan-Prieto AM, Calle-Pardo AP, Fern\u00e1ndez-Mart\u00ednez N.\nJournal of Diabetes Research, 2015:167526. (2015). doi:10.1155\/2015\/167526.<\/li>\n<\/ul>\n<ul>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26318340\">Study of the protective effect on intestinal mucosa of the hydrosoluble fiber Plantago ovata husk.<\/a><\/h4>\nSahag\u00fan AM, Vaquera J, Garc\u00eda JJ, Calle \u00c1P, Diez MJ, Fernandez N, Loro JF, Portilla HO, Sierra M.\nBMC Complementary and Alternative Medicine, 15:298. (2015). doi:10.1186\/s12906-015-0827-9.<\/li>\n<\/ul>\n<ul>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25889369\">Systemic and mammary gland disposition of enrofloxacin in healthy sheep following intramammary administration.<\/a><\/h4>\nL\u00f3pez C, Garc\u00eda JJ, Sierra M, Diez MJ, P\u00e9rez C, Sahag\u00fan AM, Fernandez N.\nBMC Veterinary Research, 11:88. (2015). doi:10.1186\/s12917-015-0406-9.<\/li>\n<\/ul>\n<ul>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25112783\">A randomised clinical trial to evaluate the effects of Plantago ovata husk in Parkinson patients: changes in levodopa pharmacokinetics and biochemical parameters.<\/a><\/h4>\nFernandez-Martinez MN, Hernandez-Echevarria L, Sierra-Vega M, Diez-Liebana MJ, Calle-Pardo A, Carriedo-Ule D, Sahag\u00fan-Prieto AM, Anguera-Vila A, Garcia-Vieitez JJ.\nBMC Complementary and Alternative Medicine, 14:296. (2014). doi:10.1186\/1472-6882-14-296.<\/li>\n<\/ul>\n<ul>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24261706\">Enrofloxacin: pharmacokinetics and metabolism in domestic animal species.<\/a><\/h4>\nL\u00f3pez-Cadenas C, Sierra-Vega M, Garc\u00eda-Vieitez JJ, Diez-Li\u00e9bana MJ, Sahag\u00fan-Prieto AM, Fern\u00e1ndez-Mart\u00ednez N.\nCurrent Drug Metabolism, 14 (10), 1042-58. (2013).<\/li>\n<\/ul>\n<ul>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23762869\">Hypoglycemic and hypolipidemic potential of a high fiber diet in healthy versus diabetic rabbits.<\/a><\/h4>\nD\u00edez R, Garc\u00eda JJ, Diez MJ, Sierra M, Sahag\u00fan AM, Calle \u00c1P, Fern\u00e1ndez N.\nBioMed Research International, 960568. (2013). doi: 10.1155\/2013\/960568.<\/li>\n<\/ul>\n<ul>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23106457\">Tissue distribution of enrofloxacin after intramammary or simulated systemic administration in isolated perfused sheep udders.<\/a><\/h4>\nL\u00f3pez Cadenas C, Fern\u00e1ndez Mart\u00ednez N, Sierra Vega M, Diez Li\u00e9bana MJ, Gonzalo Orden JM, Sahag\u00fan Prieto AM, Garc\u00eda Vieitez JJ.\nAmerican Journal of Veterinary Research, 73 (11), 1728-34. (2012).<\/li>\n<\/ul>\n<ul>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22533405\">Pharmacokinetic behavior of doxycycline after intramuscular injection in sheep.<\/a><\/h4>\nCastro Robles LJ, Sahag\u00fan Prieto AM, Diez Li\u00e9bana MJ, Fern\u00e1ndez Mart\u00ednez N, Sierra Vega M, Garc\u00eda Vieitez JJ.\nAmerican Journal of Veterinary Research, 73 (5), 714-8. (2012).<\/li>\n<\/ul>\n<ul>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22920146\">Drug interactions with the dietary fiber Plantago ovata husk.<\/a><\/h4>\nFernandez N, Lopez C, D\u00edez R, Garcia JJ, Diez MJ, Sahagun A, Sierra M.\nExpert Opinion in Drug Metabolism &amp; Toxicology, 8 (11), 1377-86. (2012).<\/li>\n<\/ul>\n<div id=\"farma_publicaciones\">\n<ul>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20694287\" target=\"_blank\" rel=\"noopener noreferrer\"> La fibra diet\u00e9tica y su interacci\u00f3n con los f\u00e1rmacos (Dietary fiber and its interaction with drugs). <\/a><\/h4>\nGonz\u00e1lez, Fern\u00e1ndez N, Sahag\u00fan A, Garc\u00eda JJ,&nbsp; Diez MJ, D\u00edez R, Sierra M. Nutrici\u00f3n Hospitalaria, 25 (4), 535-9. (2010).<\/li>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20434962\" target=\"_blank\" rel=\"noopener noreferrer\"> Effects of slowed gastrointestinal motility on levodopa pharmacokinetics. <\/a><\/h4>\nFern\u00e1ndez N, Garc\u00eda JJ,&nbsp; Diez MJ, Sahag\u00fan A, Gonz\u00e1lez A, D\u00edez R, Sierra M. Autonomic Neuroscience: Basic &amp; Clinic, 156 (1-2), 67-72. (2010).<\/li>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20384552\" target=\"_blank\" rel=\"noopener noreferrer\"> Effects of dietary factors on levodopa pharmacokinetics. <\/a><\/h4>\nFern\u00e1ndez N, Garc\u00eda JJ,&nbsp; Diez MJ, Sahag\u00fan A, D\u00edez R, Sierra M. Expert Opinion on Drug Metabolism and Toxicology, 6 (6), 1-10. (2010).<\/li>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19389862?ordinalpos=1&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noopener noreferrer\"> Effects of Plantago ovata husk on levodopa (with carbidopa) bioavailability in rabbits with autonomic gastrointestinal disorders. <\/a><\/h4>\nGarc\u00eda JJ, Fern\u00e1ndez N, Calle AP, Diez MJ, Sahag\u00fan A, Sierra. Drug Metabolism and Disposition, 37 (7), 1434-42. (2009).<\/li>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19519344?ordinalpos=1&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noopener noreferrer\"> A review of the pharmacological interactions of ivermectin in several animal species. <\/a><\/h4>\nGonz\u00e1lez-Canga A, Fern\u00e1ndez-Mart\u00ednez N, Sahag\u00fan-Prieto A, Diez Li\u00e9bana MJ, Sierra-Vega M, Garc\u00eda-Vieitez JJ. Current Drug Metabolism, 10 (4), 359-68. (2009).<\/li>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18440843?ordinalpos=19&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noopener noreferrer\"> Pharmacokinetics of doxycycline in sheep after intravenous and oral administration. <\/a><\/h4>\nCastro LJ, Sahag\u00fan AM, Diez MJ, Fern\u00e1ndez N, Sierra M,&nbsp; Garc\u00eda JJ. The Veterinary Journal, 180 (3), 389-95. (2009).<\/li>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17851096?ordinalpos=1&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noopener noreferrer\"> The pharmacokinetics and metabolism of ivermectin in domestic animal species. <\/a><\/h4>\nGonz\u00e1lez A, Sahag\u00fan AM, Diez MJ, Fern\u00e1ndez N, Sierra M,&nbsp; Garc\u00eda JJ. The Veterinary Journal, 179 (1), 25-37. (2009).<\/li>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18474374?ordinalpos=1&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noopener noreferrer\">The hydrosoluble fiber Plantago ovata husk improves levodopa (with carbidopa) bioavailability after repeated administration. <\/a><\/h4>\nDiez MJ, Garcia JJ, Prieto C, Fernandez N, Sahagun A, Sierra M. Journal of the Neurological Sciences, 271 (1-2), 15-20. (2008).<\/li>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18446504?ordinalpos=1&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noopener noreferrer\"> The pharmacokinetics and interactions of ivermectin in humans. A mini review. <\/a><\/h4>\nGonz\u00e1lez A, Sahag\u00fan AM, Diez MJ, Fern\u00e1ndez N, Sierra M,&nbsp; Garc\u00eda JJ. AAPS Journal, 10 (1), 42-6. (2008).<\/li>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18850046?ordinalpos=1&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noopener noreferrer\"> Evolution of the bioavailability and other pharmacokinetic parameters of levodopa (with carbidopa) in rabbits <\/a><\/h4>\nFernandez N, Prieto C, Sierra M, Diez MJ, Sahagun A, Gonzalez A, Garcia JJ. Methods and Findings in Experimental and Clinical Pharmacology, 30(6), 451-457. (2008).<\/li>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?Db=pubmed&amp;Cmd=ShowDetailView&amp;TermToSearch=17199426&amp;ordinalpos=8&amp;itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum\" target=\"_blank\" rel=\"noopener noreferrer\"> Bioavailability of a commercial formulation of ivermectin after subcutaneous administration to sheep <\/a><\/h4>\nGonzalez A, Sahag\u00fan, Diez MJ, Fernandez N, Sierra M, Garcia JJ. American Journal of Veterinary Research, 68 (1), 101-106. (2007).<\/li>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=16454640&amp;query_hl=7&amp;itool=pubmed_docsum\" target=\"_blank\" rel=\"noopener noreferrer\"> Pharmacokinetics of a novel formulation of ivermectin after administration to goats. <\/a><\/h4>\nGonzalez A, Sahagun AM, Diez MJ, Fernandez N, Sierra M, Garcia JJ. American Journal of Veterinary Research, 67 (2), 323-328. (2006).<\/li>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=16139166&amp;query_hl=3&amp;itool=pubmed_docsum\" target=\"_blank\" rel=\"noopener noreferrer\"> Hydrosoluble fiber (Plantago ovata husk) and levodopa I: Experimental study of the pharmacokinetic interaction. <\/a><\/h4>\nGarcia J.J., Fernandez N., Carriedo D., Diez M.J., Sahagun A., Gonzalez A., Calle A. and Sierra M. European Neuropsychopharmacology, 15(5), 497-503. (2005).<\/li>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=16139167&amp;query_hl=3&amp;itool=pubmed_docsum\" target=\"_blank\" rel=\"noopener noreferrer\"> Hydrosoluble fiber (Plantago ovata husk) and levodopa II: Experimental study of the pharmacokinetic interaction in the presence of carbidopa. <\/a><\/h4>\nFernandez N., Carriedo D., Sierra M., Diez M.J., Sahagun A., Calle, A., Gonzalez A. and Garcia J.J. European Neuropsychopharmacology, 15(5), 505-509. (2005).<\/li>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=15504383\" target=\"_blank\" rel=\"noopener noreferrer\"> Effect of glucomannan and the dosage form on ethinylestradiol oral bioavailability. <\/a><\/h4>\nGonz\u00e1lez A, Fern\u00e1ndez N, Sahag\u00fan A, Garc\u00eda JJ, Diez MJ, Castro LJ, Sierra M. Contraception, 70, 423-427. (2004).<\/li>\n \t<li>\n<h4><a href=\"http:\/\/www.grupoaulamedica.com\/web\/nutricion\/nutri12004.cfm\" target=\"_blank\" rel=\"noopener noreferrer\"> Glucomanano: propiedades y aplicaciones terap\u00e9uticas. <\/a><\/h4>\nGonz\u00e1lez A, Fern\u00e1ndez N, Sahag\u00fan A, Garc\u00eda JJ, Diez MJ, Calle AP, Castro LJ, Sierra M. Nutrici\u00f3n Hospitalaria, 19, 45-50. (2004).<\/li>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=14596467\" target=\"_blank\" rel=\"noopener noreferrer\"> Study of the hepatic first-pass of levamisole in rabbits. <\/a><\/h4>\nVillanueva, I., Diez, M.J., Garc\u00eda, J.J., Fern\u00e1ndez, N., Sahag\u00fan, A.M., Sierra, A. and Sierra, M. American Journal of Veterinary Research, 64, 1283-1287. (2003).<\/li>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=12209371\" target=\"_blank\" rel=\"noopener noreferrer\"> Therapeutic effects of Psyllium in type 2 diabetic patients <\/a><\/h4>\nM Sierra, JJ Garc\u00eda, N Fern\u00e1ndez, MJ Diez, AP Calle and Farmafibra Group* .\n* Farmafibra Group is formed by: J C \u00c1lvarez, D Carriedo, L J Castro, M de la Torre, A Gonz\u00e1lez, M A Gonz\u00e1lez, V Mor\u00e1n, C Prieto and A M Sahag\u00fan. Eur. J. Clin. Nutr., 56, 830-842. (2002).<\/li>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=12030791\" target=\"_blank\" rel=\"noopener noreferrer\"> Intra-arterial pharmacokinetics and pulmonary first-pass of levamisole in rabbits. <\/a><\/h4>\nPereda, P., Garc\u00eda, J.J., Sierra, M., Fern\u00e1ndez, N., Sahag\u00fan, A.M., and Diez M.J. Pharmacological Research, 45, 285-289. (2002).<\/li>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=11903875\" target=\"_blank\" rel=\"noopener noreferrer\"> Oral bioavailability of levamisole in goats. <\/a><\/h4>\nSahag\u00fan, A.M., Ter\u00e1n M.T., Garc\u00eda J.J., Sierra, M., Fern\u00e1ndez, N., and Diez, M.J.J. Vet. Pharmacol. Therap., 23, 189-192. (2001).<\/li>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=11360127\" target=\"_blank\" rel=\"noopener noreferrer\"> Effects of ispaghula husk and guar gum on postprandial glucose and insulin concentrations in healthy subjects. <\/a><\/h4>\nSierra M., Garc\u00eda J.J., Fern\u00e1ndez, N., Diez, M.J., Calle, A.P., Sahagun, A.M. and Farmafibra Group. Eur. J. Clin. Nutr., 55, 1-9. (2001).<\/li>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=11172796\" target=\"_blank\" rel=\"noopener noreferrer\"> Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. <\/a><\/h4>\nGarc\u00eda, J.J., Fern\u00e1ndez, N., Diez, M.J., Sahag\u00fan, A., Gonz\u00e1lez, A., Alonso, M.L., Calle, A.P. and Sierra, M. Contraception, 62, 253-257. (2000).<\/li>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=11110108\" target=\"_blank\" rel=\"noopener noreferrer\"> Subcutaneous bioavailability of levamisole in goats. <\/a><\/h4>\nSahag\u00fan, A.M., Garc\u00eda J.J., Sierra, M., Fern\u00e1ndez, N., Diez, M.J. and Ter\u00e1n M.T.J. Vet. Pharmacol. Therap., 23, 189-192. (2000).<\/li>\n \t<li>\n<h4>Influencia de las cut\u00edculas de semillas de Plantago ovata (Ispaghula husk) en la glucemia postprandial en voluntarias sanas.<\/h4>\nSierra, M., Calle, A.P., Fern\u00e1ndez, N., Diez, M.J., Sahag\u00fan, A., Su\u00e1rez, A., Garc\u00eda, J.J. y Grupo Farmafibra. Nutrici\u00f3n Hospitalaria, 14, 197-202. (1999).<\/li>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=9829032\" target=\"_blank\" rel=\"noopener noreferrer\"> Organochlorine pesticide residues in muscle tissue of rainbow trout, Oncorhynchus mykiss, taken from four fish farms in Le\u00f3n, Spain. <\/a><\/h4>\nSahag\u00fan, A.M., Ter\u00e1n, M.T., Garc\u00eda, J.J., Sierra, M., Fern\u00e1ndez, N. and Diez, M.J. Food Aditives and Contaminants, 15, 501-505. (1998).<\/li>\n \t<li>\n<h4><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=9694944\" target=\"_blank\" rel=\"noopener noreferrer\"> Influence of Two Commercial Fibers in the Pharmacokinetics of Ethinylestradiol in Rabbits. <\/a><\/h4>\nN. Fern\u00e1ndez, M.J. Diez, M.T. Ter\u00e1n, J.J. Garc\u00eda, A.P. Calle, and M. Sierra The Journal of Pharmacology and Experimental Therapeutics, 286 (2) 870-874 (1998).<\/li>\n<\/ul>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Acceso al grupo de investigaci\u00f3n FARMACOLOG\u00cdA (FARMA01) en el portal cient\u00edfico de la Universidad de Le\u00f3n. Principales publicaciones Determination of gentamicin: Development and validation of a sensitive UPLC-MS\/MS assay according to the European Medicines Agency Guideline Diez R, Vazquez EM, Romero B, de la Puente, Fernandez N, Sahag\u00fan AM, Diez MJ, Lopez C.&nbsp; Antibiotics, 15(2):130(2026). [&hellip;]<\/p>\n","protected":false},"author":122,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"ngg_post_thumbnail":0,"footnotes":""},"class_list":["post-48","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Actividad investigadora - \u00c1rea de Farmacolog\u00eda<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/departamentos.unileon.es\/ciencias-biomedicas-area-farmacologia\/actividad-investigadora\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Actividad investigadora - \u00c1rea de Farmacolog\u00eda\" \/>\n<meta property=\"og:description\" content=\"Acceso al grupo de investigaci\u00f3n FARMACOLOG\u00cdA (FARMA01) en el portal cient\u00edfico de la Universidad de Le\u00f3n. Principales publicaciones Determination of gentamicin: Development and validation of a sensitive UPLC-MS\/MS assay according to the European Medicines Agency Guideline Diez R, Vazquez EM, Romero B, de la Puente, Fernandez N, Sahag\u00fan AM, Diez MJ, Lopez C.&nbsp; Antibiotics, 15(2):130(2026). 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Principales publicaciones Determination of gentamicin: Development and validation of a sensitive UPLC-MS\/MS assay according to the European Medicines Agency Guideline Diez R, Vazquez EM, Romero B, de la Puente, Fernandez N, Sahag\u00fan AM, Diez MJ, Lopez C.&nbsp; Antibiotics, 15(2):130(2026). 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